Coyoacan is my favorite stop in Mexico City! This is where the infamous Frida Museum is. I also loved walking around the cobble stoned streets and the overall quaint feel of the town. I recommend taking an Uber there from Mexico City. There's also a metro if you want to save money, however the Uber was very affordable at around $6 for a 45 minute ride. I also recommend stopping by the Coyoacan Market, I found great souvenirs and had some delicious tacos from the most friendly vendors I've ever met. I would combine Coyoacan with Xochimilco as a day trip from Mexico City.
Points of interest
Nice little park with the coyote fountain. Great photo op.
Go to Coyoacan in the morning and take an Uber to Xochimilco for a nice afternoon!